Hi Amrrashwan
The lifetime ISA exists to help you buy your first home. which will become your main residence.
If at some point in the future, your employer relocates you to work from another part of the UK or overseas, you would be able to rent out your home while working away.
Have a look here:
HS283 Private Residence Relief (2024).
Please also have a look at the guidance on periods of absence at CG650030 onewards:
CG65030 - Private residence relief: periods of absence: introduction
You would not be required to pay back the 25% support from your lifetime ISA.
Thank you.